Zhenjia Wang

Education

PhD in physics, Changchun Institute of Physics, Chinese Academy of Sciences

Fellowships & Additional Training

Postdoctoral Fellowship, Department of Chemistry, University of Rochester, Rochester, N.Y.

Research Assistant Professor, Department of Pharmacology, University of Illinois at Chicago, Chicago, Ill.

Research

Dr. Zhenjia Wang’s research is focused on designing and generating therapeutic nanoparticles used to efficiently and effectively prevent and treat inflammatory diseases based on the understanding of molecular mechanism regulating the interactions between therapeutic nanoparticles and biological systems “in vivo”.

Strategy

Methodologies

• Design and manufacture of therapeutic nanoparticles using nanotechnology.
• Optical imaging tools (small animal molecular imaging, live cell imaging, laser scanning confocal microscopy, and intravital microscopy)
• Genetic and pharmacological approaches (knockout mouse models and molecular biology).
• Acute lung Injury and vascular Inflammation mouse models.
• Multidisciplinary collaboration at the department and college levels.

Current Projects

Additional Information

Funding Support: NIH and American Heart Association

Selected Publications

+ Denotes equal contribution; # Denotes PharmD student; * Denotes corresponding author.

Chu, D+., Dong, X+., Shi, X., Zhang, C., Wang, Z*., Neutrophil-based Drug Delivery Systems. Adv. Mater. 1706245-1706253 (2018). DOI: 10.1002/adma.201706245 (Invited Review).

Wang, S, Gao, J., Wang, Z*., Outer Membrane Vesicles (OMVs) for Vaccination and Targeted Drug Delivery. WIREs Nanomed Nanobiotechnol. https://doi.org/10.1002/wnan.1523 (2018). (Invited Review)

Yurkin, S#.,Wang, Z*., Cell-membrane-derived Nanoparticles: Emerging Clinical Opportunities for Targeted Drug Delivery. Nanomedicine (UK), 12, 2007-2019 (2017). (Online: https://www.futuremedicine.com/doi/10.2217/nnm-2017-0100).

Chu, D., Dong, X., Zhao, Q., Gu, J., Wang, Z*., Photosensitization Priming of Tumor Microenvironments Improves Delivery of Nanotherapeutics via Neutrophil Infiltration. Adv. Mater 29, 1701021-1701028 (2017).

Gao, J., Wang, S., Wang, Z*., High Yield, Scalable and Remotely Drug-loaded Neutrophil-derived Extracellular Vesicles (EVs) for Anti-inflammation Therapy. Biomaterials, 135, 62-73 (2017).

Dong, X+., Chu, D+., Wang, Z*., Nanoparticle Hitchhiking of Immune Cells for Targeted Drug Delivery. Theranostics, 7(3), 751-763 (2017).

Wang, Z*., Imaging Nanotherapeutics in Inflamed Vasculature by Intravital Microscopy Theranostics, 6 (13), 2431-2438 (2016)

Gao, J., Chu, D., Wang, Z*., Cell Membrane-formed Nanovesicles for Disease-Targeted Delivery. J. Control. Rel. 224, 208-216 (2016).

Chu, D., Zhao, Q., Yu, J., Zhang, F., Zhang, H. Wang, Z*., Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy. Adv. Healthc. Mater. 5, 1088-1093 (2016).

Chu, D., Gao, J., Wang, Z*., Neutrophil-mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection. ACS Nano 9, 11800-11811 (2015).

Wang, Z., Jing, L., Cho, J., Malik, A. B. Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nature Nanotech. 9, 204-210 (2014).

Wang, Z., Tiruppathi, C., Minshall, R. D., A. B. Malik, A. B., Size and Dynamics of Caveolae Studied using Nanoparticles in Living Endothelial Cells. ACS Nano 3(12), 4110-4116 (2009).

Wang, Z., L. J. Rothberg, L. J., Structure and Dynamics of Single Conjugated Polymer Chromophores by Surface-Enhanced Raman Spectroscopy. ACS Nano 1(4), 299-306 (2007).

Wang, Z*., Pedrosa, H., Krauss, T., Rothberg, L. J., Exciton Binding Energy in Single Walled Carbon Nanotubes. Phys. Rev. Lett. 96, 047403 (2006).

Wang, Z., Pan, S., Krauss, T. D., Du, H., Rothberg, L. J., The Structural Basis for Giant Enhancement Enabling Single-molecule Raman Scattering. Proc. Natl. Acad. Sci. USA 100, 8638 (2003)

More citations since 2001 from Google Scholar.

updated 05/08/2018