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Sergei Tolmachev

PhD
Sergei Tolmachev
Director & Professor, USTUR 509-946-6870 Suite 201 Richland

Education

PhD in chemistry, Kyushu University

Master of Science in chemical engineering, Mendeleyev University of Chemical Technology of Russia

Memberships

  • Health Physics Society
  • Radiation Research Society
  • European Radiation Dosimetry Group WG-7 on Internal Dosimetry

Additional Information

Sergei Y. Tolmachev is a research professor at the College of Pharmacy and Pharmaceutical Sciences where he directs the U.S. Transuranium and Uranium Registries (USTUR) Research Center and the associated National Human Radiobiology Tissue Repository (NHRTR). The USTUR/NHRTR is funded through federal grants and provides long term follow up of actinide biokinetics and potential health effects in nuclear workers with accidental internal depositions of these elements. Prior to this position, Tolmachev managed the radiochemistry laboratory operations and research in the fields of actinide radiochemistry and mass spectrometry, in support of internal dosimetry and actinide biokinetics research.

Current grants

U.S. Department of Energy, Manage and Operate U.S. Transuranium and Uranium Registries, PI.

Past grants

U.S. Department of Energy, USTUR: Five Decade Follow-up of Plutonium and Uranium Workers, PI.

U.S. Department of Energy, Project 2.4 Mayak Worker Dose Reconstruction, PI

Health Protection England (UK), Plutonium Binding in the Upper Airways of the Human Respiratory Tract, PI

Selected Publications

Giussani A, Lopez MA, Romm H, Testa A, Ainsbury EA, Degteva M, Della Monaca S, Etherington G, Fattibene P, Güclu I, Jaworska A, Lloyd DC, Malátová I, McComish S, Melo D, Osko J, Rojo A, Roch-Lefevre S, Shishkina E, Sotnik N, Tolmachev SY, Wieser A, Woda C, Youngman M. EURADOS review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications. Radiation and Environmental Biophysics: Published Ahead of Print 1-31; 2020. doi 10.1007/s00411-020-00845-y

Dumit S, Avtandilashvili M, McComish SL, Strom DJ, Tabatadze G, Tolmachev SY. Validation of a system of models for plutonium decorporation therapy. Radiation and Environmental Biophysics 58 (2): 227-235; 2019.

Dumit S, Avtandilashvili M, Strom DJ, McComish SL, Tabatadze G, Tolmachev SY. Improved modeling of plutonium-DTPA decorporation. Radiation Research 191 (2): 201-210; 2019.

Leggett RW, Tolmachev SY, Boice JD. Potential improvements in brain dose estimates for internal emitters. International Journal of Radiation Biology: Published Ahead of Print 1-13; 2019. doi 10.1080/09553002.2018.1554923

Health Physics Journal: USTUR 50th Anniversary Special Issue

Kathren RL, Tolmachev SY. The United States Transuranium and Uranium Registries (USTUR): A five-decade follow-up of plutonium and uranium workers. Health Physics 117 (2): 118-132; 2019.

Birchall A, Puncher M, Hodgson A, Tolmachev SY. The importance and quantification of plutonium binding in human lungs. Health Physics 117 (2): 133-142; 2019.

Goans RE, Toohey RE, Iddins CJ, McComish SL, Tolmachev SY, Dainiak N. The Pseudo-Pelger Huët cell as a retrospective dosimeter: Analysis of a Radium Dial Painter cohort. Health Physics 117 (2): 143-148; 2019.

Avtandilashvili M, Tolmachev SY. Modeling the skeleton weight of an adult Caucasian man. Health Physics 117 (2): 149-155; 2019.

Dumit S, Avtandilashvili M, Tolmachev SY. Evaluating plutonium intake and radiation dose following extensive chelation treatment. Health Physics 117 (2): 156-167; 2019.

Breustedt B, Avtandilashvili M, McComish SL, Tolmachev SY. USTUR Case 0846: Modeling americium biokinetics after intensive decorporation therapy. Health Physics 117 (2): 168-178; 2019.

Tabatadze G, Miller BW, Tolmachev SY. Mapping 241Am spatial distribution within anatomical bone structures using digital autoradiography. Health Physics 117 (2): 179-186; 2019.

Zhou JY, McComish SL, Tolmachev SY. A Monte Carlo t-test to evaluate mesothelioma and radiation in the U.S. Transuranium and Uranium Registries. Health Physics 117 (2): 187-192; 2019.

Lopez MA, Nogueira P, Vrba T, Tanner RJ, Ruhm W, Tolmachev SY. Measurements and Monte Carlo simulations of 241Am activities in three skull phantoms: EURADOS-USTUR collaboration. Health Physics 117 (2): 193-201; 2019.

Tolmachev SY, Avtandilashvili M, Kathren RL. Estimation of total skeletal content of plutonium and 241Am from analysis of a single bone. Health Physics 117 (2): 202-210; 2019.

Tolmachev SY, Swint MJ, Bistline RW, McClellan RO, McInroy JF, Kathren RL, Filipy RE, Toohey RE. USTUR special session’s roundtable – United States Transuranium and Uranium Registries (USTUR): A five-decade follow-up of plutonium and uranium workers. Health Physics 117 (2): 211-222; 2019.

Avtandilashvili M, Dumit S, Tolmachev SY. USTUR whole-body Case 0212: 17-year follow-up of plutonium contaminated wound. Radiation Protection Dosimetry 178(2): 160 – 169; 2018.

Suslova KG, Sokolova AB, Tolmachev SY, Miller SC. The Mayak Worker Dosimetry System (MWDS-2013): Estimation of plutonium skeletal burden from limited autopsy bone samples from Mayak PA workers. Radiation Protection Dosimetry 176(1-2): 117-131; 2017.

Tolmachev SY, Nielsen CE, Avtandilashvili M, Puncher M, Martinez F, Thomas EM, Miller FL, Morgan WF, Birchall A. The Mayak Worker Dosimetry System (MWDS-2013): Soluble plutonium retention in the lungs of an occupationally exposed USTUR case. Radiation Protection Dosimetry 176(1-2): 45-49; 2017.

Puncher M, Birchall A, Tolmachev SY. The Mayak Worker Dosimetry System (MWDS-2013): A re-analysis of USTUR case 0269 to determine whether plutonium binds to the lungs. Radiation Protection Dosimetry 176(1-2): 50-61; 2017.

Kathren RL, Tolmachev SY. Natural uranium tissue content of three Caucasian males. Health Physics 109: 187-197; 2015.

Avtandilashvili M, Puncher M, McComish SL, Tolmachev SY. US Transuranium and Uranium Registries case study on accidental exposure to uranium hexafluoride. Journal of Radiological Protection 35: 129-151; 2015.

Nielsen CE, Wang X, Robinson R, Brooks A, Lovaglio J, Patton K, McComish SL, Tolmachev SY, Morgan WF. Carcinogenic and inflammatory effects of plutonium-nitrate retention in an exposed nuclear worker and beagle dogs. International Journal of Radiation Biology 90: 60 – 70; 2014.

Lariviere D, Tolmachev SY, Kochermin V, Johnson S. Uranium bone content as an indicator of chronic environmental exposure from drinking water. Journal of Environmental Radioactivity 121: 98-103; 2013.

Nielsen CE, Wilson DA, Brooks AL, McCord SL, Dagle GE, James AC, Tolmachev SY, Thrall BD, Morgan WF. Microdistribution and long-term retention of 239Pu(NO3)4 in the respiratory tracts of an acutely exposed plutonium worker and experimental beagle dogs. Cancer Research 72: 5529-5536; 2012.

Lariviere D, Tremblay M, Durand-Jezequel M, Tolmachev S. Detection of beryllium in digested autopsy tissues by inductively coupled plasma mass spectrometry using a high matrix interface configuration. Analytical and Bioanalytical Chemistry 403: 409-418; 2012.

Tolmachev SY, Ketterer ME, Hare D, Doble P, James AC. The US Transuranium and Uranium Registries: Forty years’ experience and new directions in the analysis of actinides in human tissues. Proceedings in Radiochemistry – A Supplement to Radiochimica Acta 1: 173-181; 2011.

Hare D, Tolmachev S, James A, Bishop D, Austin C, Fryer F, Doble P. Elemental bio-imaging of thorium, uranium, and plutonium in tissues from occupationally exposed former nuclear workers. Analytical Chemistry 82: 3176-3182; 2010. (Featured Article, Webb S. MS maps actinides in exposed workers. Analytical Chemistry 82: 3409-3410; 2010).

Lynch TP, Tolmachev SY, James AC. Estimating 241Am activity in the body: comparison of direct measurements and radiochemical analyses. Radiation Protection Dosimetry 134: 94-101; 2009.

Selected Presentations

Brain dosimetry for internally deposited radionuclides. EURADOS 2020 Annual Meeting. Florence, Italy, January 27 – 30, 2020. (invited)

From autopsies to synchrotrons to Mars – why the brain matters. 65th Annual Meeting of the Radiation Research Society. San Diego, CA, November 3 – 6, 2019. (invited)

Uranium content, distribution, and biokinetics in human body. 74th Northwest Regional Meeting of the American Chemical Society, Portland, OR, June 16 – 19, 2019. (invited)

Plutonium in human brain: Is more biokinetic detail needed for dosimetry? 3rd International Conference on Dosimetry and its Applications. Lisbon, Portugal, May 27 – 31, 2019.

Bioimaging of samples from the United States Transuranium and Uranium Registries – shedding new light on the biokinetics, dosimetry, and possible biological effects of actinides in humans. CERAD Workshop on Particle Characteristics and Nuclear Forensic. Oslo, Norway, February 5, 2019. (invited)

Radioactive actinide particles in occupationally exposed individuals. CERAD Workshop on Health Effects Following Severe Nuclear Events. Oslo, Norway, February 3, 2019. (invited)

USTUR: Expanding horizons for actinide biokinetics and dosimetry. 12th International Conference on Health Effects of Incorporated Radionuclides, Fontenay-aux-Roses, France, October 8 – 11, 2018.

The United States Transuranium and Uranium Registries: Fifty years of contributions to understanding of plutonium in humans. 24th Meeting of the Conference on Radiation and Health Chicago, IL, September 23 – 25, 2018. (invited).

U.S. Transuranium and Uranium Registries: 50 years of research relevant to new biomarker. 62nd Annual Health Physics Society Meeting, Raleigh, NC, July 9 – July 13, 2017. (invited)

Uranium content, distribution, and biokinetics in human body. International Workshop on Uranium, Thorium, and Plutonium Sciences, Fukuoka, Japan, December 10, 2015. (invited)

Analysis of high-fired plutonium oxide and other actinides in MAPEP soil samples. 61th Radiobioassay and Radiochemical Measurements Conference. Iowa City, IA, October 25 – 30, 2015.

The National Human Radiobiology Tissue Repository. 1st International Workshop on Sample/Tissue Archiving of Radiobiology (STAR2015), Kyoto, Japan, May 24-25, 2015. (invited)

The National Human Radiobiological Tissue Repository: A unique resource for scientists. 60th Radiation Research Society Meeting, Las Vegas, NV, September 21-24, 2014. (invited)

USTUR case study on accidental exposure to uranium hexafluoride. 11th International Conference on Health Effects of Incorporated Radionuclides, Berkeley, CA, October 13-17, 2013.

The U.S. Transuranium and Uranium Registries: Beyond archiving. DoReMi/STORE Workshop on Sharing Data and Biomaterials from Radiation Science, Rome, Italy, January 25-26, 2012. (invited)

Radiochemistry Program at the U.S. Transuranium and Uranium Registries. Joint Symposium between Kyushu Environmental Evaluation Association and Kyushu University Radioisotope Center, Fukuoka, Japan, April 6, 2010. (invited)

updated 05/28/2020