K. Michael Gibson

Education

PhD in biochemistry, University of California at San Diego

Master of Science in chemistry, University of Colorado at Boulder

Bachelor of Science in chemistry, University of California at Riverside

Fellowships & Additional Training

Certified Clinical Biochemical Geneticist

Teaching

Dr. Michael Gibson’s teaching history is founded in biochemistry, genetics and health sciences. He has taught a variety of topics directly related to health sciences throughout his professional career. A selection of his previous courses includes “Human Inborn Errors of Metabolism” and “Biochemical and Molecular Genetics” at Baylor University, and “Molecular Mechanisms of Disease” and the Department of Molecular and Medical Genetics Seminar Series at Oregon Health & Science University. Gibson has given several guest lectures for “Principles of Molecular Medicine” at the University of Pittsburgh’s Graduate School of Public Health, as well as numerous other lectures to audiences of neonatology residents and fellows, medical students, lab medicine faculty, neurology fellows and interns, neuroscience graduate students, and pathology faculty, residents and interns. As Chair of Biological Sciences at Michigan Technological University, Gibson taught biochemistry to undergraduates and graduate students, and a broad course in health to undergraduates.

He has served as mentor or research advisor for PhD candidates at Southern Methodist University, Baylor University, Potchefstroom University (South Africa), and San Diego State University. He has also trained six fellows in biochemical genetics throughout his career.

Research

Gibson is a board-certified clinical biochemical geneticist, and has studied a number of Mendelian disorders of metabolism for the better part of 30 years. His research focus includes understanding the pathophysiology of selected disorders, and developing novel pre-clinical treatment approaches with translational relevance. His laboratory employs pharmacological, cellular and dietary treatment approaches in disorders such as succinic semialdehyde dehydrogenase deficiency, phenylketonuria, maple syrup urine disease, galactosemia and transaldolase deficiency, a defect of the pentose phosphate pathway. His training is in protein chemistry, molecular and neurobiology, neuropharmacology and genetics, and various analytical methodologies. His laboratory is actively interested in hepatic biology and novel approaches to liver regeneration.

Gibson is the chair of the Medical and Scientific Advisory Board of the SSADH Association, which represents children and families affected by Succinic Semialdehyde Dehydrogenase Deficiency (SSADH). Much of his research is focused on this disease.

Additional Information

Gibson joined the Washington State University College of Pharmacy in July 2012. He had been chair of the biological sciences department at Michigan Technology University in Houghton, Mich. Gibson is a past professor at the University of Pittsburgh School of Medicine and the Oregon Health & Science University in Portland.

Positions, Honors & Awards
1984-1986 Postdoctoral Fellow, Dept. Pediatrics, University of California, San Diego, La Jolla, CA
1985-1986 Bank of America-Giannini Foundation Fellow
1986-1988 Assistant Research Biochemist, Dept. Pediatrics, Univ. of California, San Diego, La Jolla, CA
1988-1998 Senior Research Scientist, Institute for Metabolic Disorders, Baylor University Medical Center and Baylor Research Institute, Dallas, Texas
1991-1992 Alexander von Humboldt Foundation Research Fellow, Heidelberg, Germany
1989-1994 Assistant Professor of Biomedical Studies, Baylor University, Waco, Texas
1989-1995 Adjunct Assistant Professor of Biological Sciences, Southern Methodist University, Dallas, TX
1994-1998 Associate Professor of Biomedical Studies, Baylor University, Waco, TX
1995-1998 Adjunct Associate Professor of Biological Sciences, Southern Methodist University, Dallas, TX
1995-1998 Adjunct Associate Professor/Neurology, Univ. Texas Southwestern Medical School, Dallas, TX
1998-2001 Associate Professor, Depts. of Molecular and Medical Genetics and Pediatrics, Oregon Health & Science University, Portland, Oregon
1998-2005 Director, Biochemical Genetics Laboratory, Oregon Health & Science University, Portland, OR
1999-2019 Board Certified Clinical Biochemical Geneticist, American College of Medical Genetics
2001-2005 Professor, Molec. and Medical Genetics, Oregon Health & Science University, Portland, OR
2004– Komrower Memorial Lecturer, Annual Meeting, Society for the Study of Inborn Errors of Metabolism, Amsterdam.
2005-2009 Director, Biochemical Genetics Laboratory, Children’s Hospital of Pittsburgh of UPMC
2005-2009 Professor, Pediatrics, Pathology, Human Genetics, University of Pittsburgh School of Medicine
2009– Pres Professor and Chair, Biological Sciences, Michigan Technological University
2008 NIH Site Visit, PDEGEN (Program in Developmental Endocrinology/Genetics), March 26-28.

Selected Publications

Pop A, Smith DEC, Kirby T, Walters D, Gibson KM, Mahmoudi S, van Dooren SJM, Kanhai WA, Fernandez-Ojeda MR, Wever EJM, Koster J, Waterham HR, Grob B, Roos B, Wamelink MMC, Chen J, Natesan S, Salomons GS. Functional analysis of thirty-four suspected pathogenic missense variants in ALDH5A1 gene associated with succinic semialdehyde dehydrogenase deficiency. Mol Genet Metab. 2020 May 4:S1096-7192(20)30110-4. doi: 10.1016/j.ymgme.2020.04.004. Epub ahead of print. PMID: 32402538.

Brown M, Turgeon C, Rinaldo P, Pop A, Salomons GS, Roullet JB, Gibson KM. Longitudinal metabolomics in dried bloodspots yields profiles informing newborn screening for succinic semialdehyde dehydrogenase deficiency. JIMD Rep. 2020 Feb 26;53(1):29-38. doi: 10.1002/jmd2.12075. PMID: 32395407; PMCID: PMC7203655.

Kirby T, Walters DC, Brown M, Jansen E, Salomons GS, Turgeon C, Rinaldo P, Arning E, Ashcraft P, Bottiglieri T, Roullet JB, Gibson KM. Correction to: Post- mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes. Metab Brain Dis. 2020 Jun;35(5):849-850. doi: 10.1007/s11011-020-00569-4. Erratum for: Metab Brain Dis. 2020 Apr;35(4):601-614. PMID: 32306187; PMCID: PMC7228844.

Kirby T, Walters DC, Brown M, Jansen E, Salomons GS, Turgeon C, Rinaldo P, Arning E, Ashcraft P, Bottiglieri T, Roullet JB, Gibson KM. Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes. Metab Brain Dis. 2020 Apr;35(4):601-614. doi: 10.1007/s11011-020-00550-1. Epub 2020 Mar 14. Erratum in: Metab Brain Dis. 2020 Apr 18;: PMID: 32172518; PMCID: PMC7180121.

Chan K, Hoon M, Pattnaik BR, Ver Hoeve JN, Wahlgren B, Gloe S, Williams J, Wetherbee B, Kiland JA, Vogel KR, Jansen E, Salomons G, Walters D, Roullet JB, Gibson KM, McLellan GJ. Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):17. doi: 10.1167/iovs.61.2.17. PMID: 32053727.

Brown M, Turgeon C, Rinaldo P, Roullet JB, Gibson KM. Temporal metabolomics in dried bloodspots suggests multipathway disruptions in aldh5a1^-/- mice, a model of succinic semialdehyde dehydrogenase deficiency. Mol Genet Metab. 2019 Dec;128(4):397-408. doi: 10.1016/j.ymgme.2019.10.003. Epub 2019 Oct 31. PMID: 31699650.

Brown M, Ashcraft P, Arning E, Bottiglieri T, Roullet JB, Gibson KM. Gamma- Hydroxybutyrate content in dried bloodspots facilitates newborn detection of succinic semialdehyde dehydrogenase deficiency. Mol Genet Metab. 2019 Sep- Oct;128(1-2):109-112. doi: 10.1016/j.ymgme.2019.07.010. Epub 2019 Jul 18. PMID: 31345667; PMCID: PMC6961708.

Kirby TO, Brown M, Ochoa-Repáraz J, Roullet JB, Gibson KM. Microbiota Manipulation as a Metagenomic Therapeutic Approach for Rare Inherited Metabolic Disorders. Clin Pharmacol Ther. 2019 Sep;106(3):505-507. doi: 10.1002/cpt.1503. Epub 2019 Jul 4. PMID: 31273774; PMCID: PMC6692240.

Gibson KM, Nguyen BN, Neumann LM, Miller M, Buss P, Daniels S, Ahn MJ, Crandall KA, Pukazhenthi B. Gut microbiome differences between wild and captive black rhinoceros – implications for rhino health. Sci Rep. 2019 May 28;9(1):7570. doi: 10.1038/s41598-019-43875-3. PMID: 31138833; PMCID: PMC6538756.

Brown MN, Walters DC, Schmidt MA, Hill J, McConnell A, Jansen EEW, Salomons GS, Arning E, Bottiglieri T, Gibson KM, Roullet JB. Maternal glutamine supplementation in murine succinic semialdehyde dehydrogenase deficiency, a disorder of γ-aminobutyric acid metabolism. J Inherit Metab Dis. 2019 Sep;42(5):1030-1039. doi: 10.1002/jimd.12107. Epub 2019 May 29. PMID: 31032972.

Pop A, Struys EA, Jansen EEW, Fernandez MR, Kanhai WA, van Dooren SJM, Ozturk S, van Oostendorp J, Lennertz P, Kranendijk M, van der Knaap MS, Gibson KM, van Schaftingen E, Salomons GS. D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants. Hum Mutat. 2019 Jul;40(7):975-982. doi: 10.1002/humu.23751. Epub 2019 Apr 13. PMID: 30908763; PMCID: PMC6619364.

Gibson KM, Steiner MC, Kassaye S, Maldarelli F, Grossman Z, Pérez-Losada M, Crandall KA. A 28-Year History of HIV-1 Drug Resistance and Transmission in Washington, DC. Front Microbiol. 2019 Mar 8;10:369. doi: 10.3389/fmicb.2019.00369. Erratum in: Front Microbiol. 2019 Nov 12;10:2590. PMID: 30906285; PMCID: PMC6418020.

Brown M, Ashcraft P, Arning E, Bottiglieri T, McClintock W, Giancola F, Lieberman D, Hauser NS, Miller R, Roullet JB, Pearl P, Gibson KM. Rett syndrome (MECP2) and succinic semialdehyde dehydrogenase (ALDH5A1) deficiency in a developmentally delayed female. Mol Genet Genomic Med. 2019 May;7(5):e629. doi: 10.1002/mgg3.629. Epub 2019 Mar 4. PMID: 30829465; PMCID: PMC6503008.

Walters DC, Arning E, Bottiglieri T, Jansen EEW, Salomons GS, Brown MN, Schmidt MA, Ainslie GR, Roullet JB, Gibson KM. Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues. Neurochem Int. 2019 May;125:151-162. doi: 10.1016/j.neuint.2019.02.015. Epub 2019 Feb 26. PMID: 30822440; PMCID: PMC6414070.

Bose M, Mahadevan M, Schules DR, Coleman RK, Gawron KM, Gamble MB, Roullet JB, Gibson KM, Rizzo WB. Emotional experience in parents of children with Zellweger spectrum disorders: A qualitative study. Mol Genet Metab Rep. 2019 Feb 14;19:100459. doi: 10.1016/j.ymgmr.2019.100459. PMID: 30815361; PMCID: PMC6377409.

DiBacco ML, Roullet JB, Kapur K, Brown MN, Walters DC, Gibson KM, Pearl PL. Age-related phenotype and biomarker changes in SSADH deficiency. Ann Clin Transl Neurol. 2018 Dec 3;6(1):114-120. doi: 10.1002/acn3.696. PMID: 30656189; PMCID: PMC6331944.

Walters DC, Jansen EEW, Ainslie GR, Salomons GS, Brown MN, Schmidt MA, Roullet JB, Gibson KM. Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use- limiting visual field defects. Pharmacol Res Perspect. 2019 Jan 7;7(1):e00456. doi: 10.1002/prp2.456. PMID: 30631446; PMCID: PMC6321982.

Bi W, Bi Y, Li P, Hou S, Yan X, Hensley C, Bammert CE, Zhang Y, Gibson KM, Ju J, Bi L. Indole Alkaloid Derivative B, a Novel Bifunctional Agent That Mitigates 5-Fluorouracil-Induced Cardiotoxicity. Version 2. ACS Omega. 2018 Nov 30;3(11):15850-15864. doi: 10.1021/acsomega.8b02139. Epub 2018 Nov 21. PMID: 30533582; PMCID: PMC6275955.

Vogel KR, Ainslie GR, Walters DC, McConnell A, Dhamne SC, Rotenberg A, Roullet JB, Gibson KM. Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies. J Inherit Metab Dis. 2018 Jul;41(4):699-708. doi: 10.1007/s10545-018-0153-8. Epub 2018 Feb 19. PMID: 29460030; PMCID: PMC6041169.

Gibson KM, Nesbitt A, Cao K, Yu Z, Denenberg E, DeChene E, Guan Q, Bhoj E, Zhou X, Zhang B, Wu C, Dubbs H, Wilkens A, Medne L, Bedoukian E, White PS, Pennington J, Luo M, Conlin L, Monos D, Sarmady M, Marsh E, Zackai E, Spinner N, Krantz I, Deardorff M, Santani A. Correction: Novel findings with reassessment of exome data: implications for validation testing and interpretation of genomic data. Genet Med. 2018 Nov;20(11):1486. doi: 10.1038/gim.2018.1. Erratum for: Genet Med. 2018 Mar;20(3):329-336. PMID: 29419820.

Gibson KM, Nesbitt A, Cao K, Yu Z, Denenberg E, DeChene E, Guan Q, Bhoj E, Zhou X, Zhang B, Wu C, Dubbs H, Wilkens A, Medne L, Bedoukian E, White PS, Pennington J, Luo M, Conlin L, Monos D, Sarmady M, Marsh E, Zackai E, Spinner N, Krantz I, Deardorff M, Santani A. Novel findings with reassessment of exome data: implications for validation testing and interpretation of genomic data. Genet Med. 2018 Mar;20(3):329-336. doi: 10.1038/gim.2017.153. Epub 2017 Oct 12. Erratum in: Genet Med. 2018 Feb 08;: Erratum in: Genet Med. 2018 Oct;20(10):1298. PMID: 29389922.

Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Roullet JB, Gibson KM. In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells. PLoS One. 2017 Oct 20;12(10):e0186919. doi: 10.1371/journal.pone.0186919. PMID: 29053743; PMCID: PMC5650182.

Vogel KR, Ainslie GR, McConnell A, Roullet JB, Gibson KM. Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder. Toxicol In Vitro. 2018 Feb;46:203-212. doi: 10.1016/j.tiv.2017.10.015. Epub 2017 Oct 12. PMID: 29031482; PMCID: PMC5842807.

Wong SY, Gadomski T, van Scherpenzeel M, Honzik T, Hansikova H, Holmefjord KSB, Mork M, Bowling F, Sykut-Cegielska J, Koch D, Hertecant J, Preston G, Jaeken J, Peeters N, Perez S, Nguyen DD, Crivelly K, Emmerzaal T, Gibson KM, Raymond K, Abu Bakar N, Foulquier F, Poschet G, Ackermann AM, He M, Lefeber DJ, Thiel C, Kozicz T, Morava E. Oral D-galactose supplementation in PGM1-CDG. Genet Med. 2017 Nov;19(11):1226-1235. doi: 10.1038/gim.2017.41. Epub 2017 Jun 15. PMID: 28617415; PMCID: PMC5675745.

Nykamp K, Anderson M, Powers M, Garcia J, Herrera B, Ho YY, Kobayashi Y, Patil N, Thusberg J, Westbrook M; Invitae Clinical Genomics Group, Topper S. Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria. Genet Med. 2017 Oct;19(10):1105-1117. doi: 10.1038/gim.2017.37. Epub 2017 May 11. Erratum in: Genet Med. 2020 Jan;22(1):240-242. PMID: 28492532; PMCID: PMC5632818.

Koenig MK, Hodgeman R, Riviello JJ, Chung W, Bain J, Chiriboga CA, Ichikawa K, Osaka H, Tsuji M, Gibson KM, Bonnen PE, Pearl PL. Phenotype of GABA- transaminase deficiency. Neurology. 2017 May 16;88(20):1919-1924. doi: 10.1212/WNL.0000000000003936. Epub 2017 Apr 14. PMID: 28411234; PMCID: PMC5444310.

Johansen SS, Wang X, Sejer Pedersen D, Pearl PL, Roullet JB, Ainslie GR, Vogel KR, Gibson KM. Gamma-Hydroxybutyrate (GHB) Content in Hair Samples Correlates Negatively with Age in Succinic Semialdehyde Dehydrogenase Deficiency. JIMD Rep. 2017;36:93-98. doi: 10.1007/8904_2017_3. Epub 2017 Feb 18. PMID: 28213850; PMCID: PMC5680286.

Vogel KR, Ainslie GR, Roullet JB, McConnell A, Gibson KM. In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding. Toxicol In Vitro. 2017 Apr;40:196-202. doi: 10.1016/j.tiv.2017.01.013. Epub 2017 Jan 22. PMID: 28119166.

Vogel KR, Ainslie GR, Pearl PL, Gibson KM. Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity? Clin Pharmacol Ther. 2017 Apr;101(4):458-461. doi: 10.1002/cpt.581. Epub 2017 Feb 7. PMID: 27864823; PMCID: PMC5801739.

Attri SV, Singhi P, Wiwattanadittakul N, Goswami JN, Sankhyan N, Salomons GS, Roullett JB, Hodgeman R, Parviz M, Gibson KM, Pearl PL. Incidence and Geographic Distribution of Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency. JIMD Rep. 2017;34:111-115. doi: 10.1007/8904_2016_14. Epub 2016 Nov 5. PMID: 27815844; PMCID: PMC5509553.

Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Gibson KM. Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):33-42. doi: 10.1016/j.bbadis.2016.10.009. Epub 2016 Oct 17. PMID: 27760377; PMCID: PMC5154833.

Recent Presentations

Boston Children’s Hospital and the Department of Neurology, Harvard Medical, Epilepsy Research Seminar, Division of Epilepsy and Clinical Neurophysiology, April 16, 2015, “The GABA-mTOR-mitophagy Triad: Therapeutic Insights for Disordered GABA Metabolism and Vigabatrin-Induced Toxicity”, Host: Dr. Phillip Pearl.

Department of Integrated Physiology and Neuroscience, Washington State University, Pullman, WA. “Man, Mice and Drugs: A Genetic Odyssey in a Heritable Disorder of GABA Metabolism”. Host: Dr. Steven Simasko, Nov. 13, 2015.

SSADH Symposium: A Focus on a Rare Neurotransmitter Disease, March 31-April 1, 2016. Sponsored by Boston Children’s Hospital, Dept. of Neurology. “Historical Timeline of SSADH Deficiency”.

updated 06/04/2020